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UK DRI Research Assistant

£40,774 - £40,774
 

Job Description

Dementia is the greatest health challenge of our century.



To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.



The UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.



We are a globally leading multidisciplinary research institute of 700 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at University College London, the University of Cambridge, Cardiff University, Edinburgh University, Imperial College London and King’s College London.



 



Centre context



 



King’s 



Researchers at the UK DRI at King’s use innovative approaches to explore the biological mechanisms involved in neurodegenerative diseases. Their goal is to defeat dementia by uncovering vital new knowledge that will lead to the design of smarter diagnostics and effective treatments. The team aim to understand the fundamental biological processes involved in dementia at a molecular level – and to use that knowledge to design new ways to diagnose and treat disease more precisely.



 



The group of Dr Marc-David Ruepp is seeking an organised and enthusiastic individual for a full-time research assistant position to support their research. This position will involve significant work in molecular cloning, analysis of changes in gene expression by RT-PCR and qPCR, mammalian cell culture, and splicing modulation and thus requires consistency and attention to detail, as well as a willingness for occasional weekend work in the context of cellular work. The post-holder will also provide support for general organisational and technical duties to allow the smooth and efficient running of the lab.



Dr Marc-David Ruepp’s group works on RNA metabolism in health and disease with a specific focus on the two neurodegenerative diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This position will provide valuable research support and contribute to the understanding of ALS/FTD in order to find effective therapeutic strategies.




  • Maintenance of cell cell cultures

  • Perform molecular biology, biochemistry, and imaging assays

  • Maintaining accurate laboratory records

  • Manage the ordering of laboratory supplies and equipment

  • Liaising with other technical staff to service and maintain stocks and equipment

  • Undertake any other reasonable duties that may be requested by Dr Marc-David Ruepp

  • Requires flexibility for occasional weekend work



Qualifications

Qualifications




  • BSc/MSci in Neuroscience or related discipline



Skills

Essential Skills




  • Experience in mammalian cell culture

  • Experience in molecular biology

  • Experience in preparing buffers and media

  • Experience in molecular biology: Nucleic acid isolation, RT, qPCR

  • Experience in splicing modulation using modified snRNAs

  • Experience in C++, Java, R and Graph Pad Prism

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Job Description: Research Assistant (participatory toolkit: engaging with young communities)



 



The aim is to produce a toolkit designed to help researchers and practitioners to employ participatory methods when working with young people. The research assistant will also be working alongside researchers and stakeholders to understand ‘youth voice,’ youth social action and solutions to issues facing young Londoners.



 



The toolkit will draw on our experiences of participatory research with and for young people; especially, the process of involving young people as peer researchers (16- to 25-year-olds) within our existing ‘Youth Social Action’ project commissioned by the Greater London Authority. In addition to analyse the findings, the young steering group members challenge us methodologically and epistemologically, and have thus developed innovative approaches and methods that not only will enhance the research, but also make the ‘Youth Social Action’ project more meaningful, empowering and engaging to the young people involved.



The project consists of two components: (1) research with Key Stage 3 students (12- to 14-year-olds) where the key part of the qualitative data is collected through school workshops; and, (2) research with 16- to 25-year-olds, where the data is collected through interactive activities, as part of the ‘Young Changemakers’ event, scheduled to take place on 12 July 2024 at London Metropolitan University.



Qualifications

This is a great opportunity for a graduate student or PGR student who want to further develop skills around academic research (qualitative), writing and delivering of school workshops.



Skills

To support this project, we need two research assistants to support us with the following tasks:



Conduct desk-based research




  • Help capture the youth participatory approach applied on the project.

  • Undertake literature searches as appropriate, and a literature review around participatory research involving young people.

  • Assist in the analysis of qualitative data, as directed by the research leads.

  • Summarise the key findings of the activities.



Presentation of findings




  • Assist with the presentation of findings.

  • Participate in the documentation of the results arising from research activity.

  • Contribute towards the publication of the toolkit.



Planning and managing resources




  • Work to deadlines and manage competing priorities, with direction as appropriate from project leads.



University/school profile




  • As appropriate, liaise with relevant internal and external contacts/organisations in related areas of study.



Delivery of project




  • Assist with planning and delivery of an event, taking place at London Metropolitan University, where the aim is to run fun, interactive research activities for 16- to 25-year-olds.

  • Assist with planning and delivery of two workshops for Key Stage 2 students, scheduled to take place in a school in Camden, London, on 15 and 16 July, 2024.

The Laboratory of RNA networks is seeking a Research Assistant  to join a team of researchers under the supervision of Professor Jernej Ule working on the dynamics of ribonucleoprotein complexes (RNP) that assemble on the 3’ UTRs of neuronal mRNAs (http://ulelab.info/). The group focuses on mechanisms of RNP assembly, as part of a project funded by the Wellcome Trust. 



The post holder will contribute to the project to develop computational approaches to study how RNA-binding proteins  regulate alternative splicing. Primary focus will be computational studies of data produced by iCLIP, RNA-seq and related methods) and developing the work towards relevant publications. 



The post is based at the UK DRI, https://ukdri.ac.uk/ 



Maurice Wohl Clinical Neuroscience Institute, King's College, Denmark Hill Campus  





  • To conduct high quality research under the supervision of Professor Ule, and in collaboration with other members of the Ule group. 




  • Develop and test new software, analyse data, build new hypotheses and independently design further experiments. 







  • Prepare figures summarising the results and play a leading role in writing the manuscripts. 




  • Continue professional development, including participation in staff development and review procedures in accordance with UCL guidelines, including annual formal appraisal 




  • Contribute to the department’s multidisciplinary research projects within the strategy. 




  • Present at international conferences as well as internal meetings at UCL, and meetings with external collaborators. 




  • Regularly interact with collaborators and coordinate joint work. 







  • Ensuring the highest standard of record keeping, maintaining accurate, complete, and up to date records. 




  • Ensuring confidentiality is maintained as applicable. 




  • Attending and contributing to Departmental, Institutional and other meetings as appropriate. 




  • Acting at all times in accordance with the highest professional standards, and ensuring that these are maintained in the delivery of all aspects of researc





Qualifications

PhD in Computational Biology or a related discipline 



Skills


  • Experience in developing new computational tool 




  • Experience with mechanisms of RNA regulation 




  • Computational proficiency at advanced level 




  • Excellent oral and written communication skills 







  • Strong problem solving abilities 




  • Excellent organisational skills, with the ability to work efficiently on multiple sites 




  • Excellent inter-personal skills with an ability to work co-operatively in a multidisciplinary setting 




  • Resourceful and able to act on own initiative 




  • Interested in research and a commitment to supporting high quality research 







  • Meticulous and accurate in all aspects of work 

     



Teaching fellow with neuroscience knowledge for urgent level 6 marking



Qualifications

Ideally HEA fellowship



Skills

Marking

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