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Job Description
We are looking to employ a Research Associate / Research Assistant to lead on a Patient and Public Involvement (PPI) project with bariatric surgery patients and to support the launch of a psychology research database. This will be on a fixed-term basis until 31st July (21 hours per week) and pay is equivalent to a Research Associate (G6, spine 31) at £23.67 per hour, or Research Assistant (G5, spine 25) at £20.46.
The PPI element of this role will involve recruiting a diverse group of patient representatives from different backgrounds (identified by NHS staff) and exploring their views and feedback on research topics, their experience of the bariatric surgery, gaps in care, and recommendations. The researcher will conduct interviews and engage with PPI representatives to review and iterate documents where needed. The goal is to also set up a PPI panel for ongoing input where needed, and the researcher will produce a brief report.
The other component of this role may involve liaising with NHS collaborators and providing research set-up support linked to implementation of the research database. The researcher may be required to host a stakeholder meeting and will assist with ongoing needs of the project, where relevant. Other tasks may arise for the researcher to feed into on different projects.
Qualifications
- A PhD or Doctorate (or equivalent) in a related subject area (e.g. psychology, medicine, health) is required for appointment at Research Associate level.
- Students completing a PhD or Doctorate (or equivalent) who wish to dovetail this work will be considered for appointment at Research Assistant level.
Skills
- Experience of conducting participant interviews and/or carrying out PPI work.
- Experience of working with health populations, clinical research, and/or in psychology is desirable.
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Triple-negative breast cancer (TNBC) is a heterogeneous type of breast cancer lacking estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (HER2) expression. The high heterogeneity of TNBC has been widely suggested as the reason for poor responses to targeted therapies. While changes in the coding and regulatory genome have been studied in detail, how 40% of the genome comprising the retrotransposable elements (REs) might impact the biology of TNBC is unknown. The aberrant activation of REs and their contribution to oncogenesis of solid tumours have been recently investigated. However, studying the oncogenic and immunogenic roles of REs in TNBC is lagging mainly because of the heterogeneity of this disorder.
Our central hypothesis is that ectopic transcriptional activation of REs in different subtypes of TNBC leads to significant changes in expression of specific genes, a subset of which may play a direct role in tumorigenesis of this malignancy. To address this hypothesis, We need to functionally validate predicted oncogenic and immunogenic REs through the specific aims:
1) Validation of prioritized oncogenic RE-derived chimeric transcripts
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Triple-negative breast cancer (TNBC) is a heterogeneous type of breast cancer lacking estrogen receptor (ER), progesterone receptor (PR), and human epithelial growth factor receptor 2 (HER2) expression. The high heterogeneity of TNBC has been widely suggested as the reason for poor responses to targeted therapies. While changes in the coding and regulatory genome have been studied in detail, how 40% of the genome comprising the retrotransposable elements (REs) might impact the biology of TNBC is unknown. The aberrant activation of REs and their contribution to oncogenesis of solid tumours have been recently investigated. However, studying the oncogenic and immunogenic roles of REs in TNBC is lagging mainly because of the heterogeneity of this disorder.
Our central hypothesis is that ectopic transcriptional activation of REs in different subtypes of TNBC leads to significant changes in expression of specific genes, a subset of which may play a direct role in tumorigenesis of this malignancy. To address this hypothesis, We need to functionally validate predicted oncogenic and immunogenic REs through the specific aims:
1) Validation of prioritized oncogenic RE-derived chimeric transcripts
2) Immunopeptidome validation of high-affinity scoring RE peptides
The successful candidate will review a set of lecture notes and slides designed for an undergraduate mathematics course. The course covers fundamental topics such as basic mathematical functions, trigonometry, differentiation, integration, and introductory probability theory and inference.
The candidate?s primary responsibility will be to help to bridge the gap between mathematics and the natural sciences by relating the mathematical content to examples from the sciences and by linking the mathematical formalism to conventions (mathematical notation etc.) more commonly used in scientific disciplines. There will also be the opportunity to work with staff in the maths department on the formatting and presentation of content and on the design of assessments.
Qualifications
Undergraduate level or higher degree in a mathematical science (Engineering or Physics preferred)
Skills
- A good understanding of the mathematics required for undergraduate science programmes is essential.
- Experience of delivering undergraduate level mathematics tuition is desirable.
- Experience of supporting preparation of teaching materials for undergraduate mathematics teaching is desirable.
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