UK DRI Research Associate

£46,157 - £46,157

Job Description

Dr Sarah Marzi https://ukdri.ac.uk/team/sarah-marzi) is seeking to appoint a Research Associate, her research programme aims to determine the role of epigenetic regulation in neurodegenerative diseases, including ALS, Parkinson’s, and Alzheimer’s disease, using state of the art epigenetic and genomic techniques in cell populations and at the single cell level. Specifically, we seek to identify an epigenetic link between non-coding genetic and environmental risk in dementia and identify mechanisms by which these risk factors make cells susceptible to neurodegeneration.



 



The successful candidate should have substantial experience in the analysis of epigenetic and transcriptomic data, particularly chromatin profiling to lead on research identifying disease-linked epigenetic regulation in post-mortem brain samples. Experience with bioinformatic analyses more generally and use of a high-performance computing cluster will be essential. You will be a dynamic, creative, and motivated scientist interested in pursuing questions deeply. With strong molecular biology knowledge and experience with genomic/epigenomic approaches, you will use a range of methods for brain tissue analyses including next generation RNA sequencing, ChIP sequencing and CUT&Tag/TIP-seq (or equivalent) and ATAC sequencing methods. Reproducibility is of particular importance to the Marzi lab, and experience with version control, github, and/or interactive/annotated reporting with a markup language will be a plus.



 



The Marzi Lab is highly collaborative. You will join a multidisciplinary team on the Denmark Hill Campus with a leading role in:



 



•            Designing and performing experiments



•            Developing technical advances



•            Performing data analysis



•            Presenting the results



•            Writing up manuscripts to be submitted to peer-review journals



 



Post holders will be given opportunities to work closely with a broad range of other scientists across the UK DRI and in external universities. It is recognised that new ideas always are needed in the field and post holders will be given opportunities to explore their own and other novel ideas, train in new methods and develop new competencies. King’s College also encourages continued professional development of its staff through both internal and external educational courses covering skills such as project, financial or time management and communication, as well as scientific topics.



The post holder will be supported to attend scientific meetings to present work, subject to progress and budgets.  plasmid and vector constructs and quantify the effects on target gene expression. For in vivo they will sacrifice rodents and harvest and prepare tissues for histological sectioning, staining, imaging, and quantitative analyses. All experiments will be undertaken at a very high standard and all data treated with complete confidentiality.



 



 



 



 



 




Qualifications

PhD in Molecular Biology, Neuroscience or Bioinformatics, or a closely related discipline, or equivalent research, industrial or commercial experience.



Skills

  1. Hold a PhD in Molecular Biology, Neuroscience or Bioinformatics, or a closely related discipline, or equivalent research, industrial or commercial experience.

  2. Practical experience within a research environment and publication in relevant and refereed journals or preprints

  3. Knowledge of next-generation genomic approaches, specifically those pertaining to chromatin biology.

  4. Practical experience in bioinformatic analyses, including pre-processing, quality control and differential analysis of gene expression and chromatin data.

  5. Practical experience in a broad range of standard laboratory techniques including light microscopy and molecular biology (e.g., immunofluorescence on brain tissue, cloning, qPCR, cell culture)

  6. Practical experience some or all of the following high-throughput genomics techniques:




  • ATAC-sequencing

  • RNA-sequencing

  • Chromatin immunoprecipitation (ChIP) sequencing

  • Cleavage Under Targets and Tagmentation (CUT&Tag)

  • Targeted insertion of promoters sequencing (TIP-seq)

  • Single cell or single nuclear genomics method

     



7. Experience working with single cell/nuclei disassociation protocols.



 



8. Excellent written communication skills and the ability to write clearly and succinctly for publication and conduct a detailed review of recent literature.



 



Desirable criteria



         1. Experience working with bio-banked tissue



         2. Experience working with rodent brain dissections



         3. Experience with flow symmetry

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Research Temp 




Qualifications

N/A



Skills

Research Experience 

The Global Mobility Office (also known as GloMo) is seeking four current King’s students to join us as Peer Advisors for the 2024/25 academic year.  We encourage applications from students from underrepresented and widening participation backgrounds



We are looking for someone friendly, enthusiastic and reliable who has previously studied or worked abroad on a placement facilitated through GloMo (i.e. Summer exchange or a semester/year abroad as part of your degree).  You should have an interest in international education and an awareness of the value of experiencing different cultures.   



This role will involve assisting with the incoming Study Abroad Orientation week in both September and January (welcoming approximately 1000 students across the academic year), as well as other events during the year for both incoming and outgoing students.  You’ll spend two hours per week in the GloMo office working on other administrative tasks and projects, which will vary depending on the office’s needs and your particular skills.  You will also act as an advisor to outgoing students, by talking about your own experiences and challenges whilst studying abroad, and assisting with events such as pre-departure meetings. 



You must be available for the September 2024 (16th – 20th) and January 2025 (8th – 11th) orientation periods to be eligible for this position.  The role will begin from early September 2024 (exact start date can be negotiated, but ideally week commencing 2nd September) and will finish at the end of April 2025. 



Interviews will be held week commencing 12th August via Teams. 



To apply for the position, please apply via this advert and complete our application form online.   If you have any questions about your eligiblity for this role, please contact Sarah Goodyear, Global Mobility Senior Officer (Incoming Students Coordinator) at sarah.goodyear@kcl.ac.uk




Qualifications

N/A



Skills

You must have studied or worked abroad as part of your degree or facilitated by Global Mobility.



Not essential but beneficial:



Administrative experience



Ambassador experience



Customer service experience

The Global Mobility Office (also known as GloMo) is seeking four current King’s students to join us as Peer Advisors for the 2024/25 academic year.  We encourage applications from students from underrepresented and widening participation backgrounds



We are looking for someone friendly, enthusiastic and reliable who has previously studied or worked abroad on a placement facilitated through GloMo (i.e. Summer exchange or a semester/year abroad as part of your degree).  You should have an interest in international education and an awareness of the value of experiencing different cultures.   



This role will involve assisting with the incoming Study Abroad Orientation week in both September and January (welcoming approximately 1000 students across the academic year), as well as other events during the year for both incoming and outgoing students.  You’ll spend two hours per week in the GloMo office working on other administrative tasks and projects, which will vary depending on the office’s needs and your particular skills.  You will also act as an advisor to outgoing students, by talking about your own experiences and challenges whilst studying abroad, and assisting with events such as pre-departure meetings. 



You must be available for the September 2024 (16th – 20th) and January 2025 (8th – 11th) orientation periods to be eligible for this position.  The role will begin from early September 2024 (exact start date can be negotiated, but ideally week commencing 2nd September) and will finish at the end of April 2025. 



Interviews will be held week commencing 12th August via Teams. 



To apply for the position, please apply via this advert and complete our application form online.   If you have any questions about your eligiblity for this role, please contact Sarah Goodyear, Global Mobility Senior Officer (Incoming Students Coordinator) at sarah.goodyear@kcl.ac.uk




Qualifications

N/A



Skills

You must have studied or worked abroad as part of your degree or facilitated by Global Mobility.



Not essential but beneficial:



Administrative experience



Ambassador experience



Customer service experience

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