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You can view related vacancies or set-up an email alert notification when similar jobs are added to the website below.
UK DRI Research Associate
Job Description
Dr Sarah Marzi https://ukdri.ac.uk/team/sarah-marzi) is seeking to appoint a Research Associate, her research programme aims to determine the role of epigenetic regulation in neurodegenerative diseases, including ALS, Parkinson’s, and Alzheimer’s disease, using state of the art epigenetic and genomic techniques in cell populations and at the single cell level. Specifically, we seek to identify an epigenetic link between non-coding genetic and environmental risk in dementia and identify mechanisms by which these risk factors make cells susceptible to neurodegeneration.
The successful candidate should have substantial experience in the analysis of epigenetic and transcriptomic data, particularly chromatin profiling to lead on research identifying disease-linked epigenetic regulation in post-mortem brain samples. Experience with bioinformatic analyses more generally and use of a high-performance computing cluster will be essential. You will be a dynamic, creative, and motivated scientist interested in pursuing questions deeply. With strong molecular biology knowledge and experience with genomic/epigenomic approaches, you will use a range of methods for brain tissue analyses including next generation RNA sequencing, ChIP sequencing and CUT&Tag/TIP-seq (or equivalent) and ATAC sequencing methods. Reproducibility is of particular importance to the Marzi lab, and experience with version control, github, and/or interactive/annotated reporting with a markup language will be a plus.
The Marzi Lab is highly collaborative. You will join a multidisciplinary team on the Denmark Hill Campus with a leading role in:
• Designing and performing experiments
• Developing technical advances
• Performing data analysis
• Presenting the results
• Writing up manuscripts to be submitted to peer-review journals
Post holders will be given opportunities to work closely with a broad range of other scientists across the UK DRI and in external universities. It is recognised that new ideas always are needed in the field and post holders will be given opportunities to explore their own and other novel ideas, train in new methods and develop new competencies. King’s College also encourages continued professional development of its staff through both internal and external educational courses covering skills such as project, financial or time management and communication, as well as scientific topics.
The post holder will be supported to attend scientific meetings to present work, subject to progress and budgets. plasmid and vector constructs and quantify the effects on target gene expression. For in vivo they will sacrifice rodents and harvest and prepare tissues for histological sectioning, staining, imaging, and quantitative analyses. All experiments will be undertaken at a very high standard and all data treated with complete confidentiality.
Qualifications
PhD in Molecular Biology, Neuroscience or Bioinformatics, or a closely related discipline, or equivalent research, industrial or commercial experience.
Skills
- Hold a PhD in Molecular Biology, Neuroscience or Bioinformatics, or a closely related discipline, or equivalent research, industrial or commercial experience.
- Practical experience within a research environment and publication in relevant and refereed journals or preprints
- Knowledge of next-generation genomic approaches, specifically those pertaining to chromatin biology.
- Practical experience in bioinformatic analyses, including pre-processing, quality control and differential analysis of gene expression and chromatin data.
- Practical experience in a broad range of standard laboratory techniques including light microscopy and molecular biology (e.g., immunofluorescence on brain tissue, cloning, qPCR, cell culture)
- Practical experience some or all of the following high-throughput genomics techniques:
- ATAC-sequencing
- RNA-sequencing
- Chromatin immunoprecipitation (ChIP) sequencing
- Cleavage Under Targets and Tagmentation (CUT&Tag)
- Targeted insertion of promoters sequencing (TIP-seq)
- Single cell or single nuclear genomics method
7. Experience working with single cell/nuclei disassociation protocols.
8. Excellent written communication skills and the ability to write clearly and succinctly for publication and conduct a detailed review of recent literature.
Desirable criteria
1. Experience working with bio-banked tissue
2. Experience working with rodent brain dissections
3. Experience with flow symmetry
MORE JOBS LIKE THIS
OSCE Invigilation
Thursday 1st May 2025 & Friday 2nd May 2025.
Applicants must NOT be part of the MPharm course at King's College London or the Faculty of Life Sciences and Medicine.
Key responsibilities
- To support the Lead Invigilator in carrying out their duties by attending briefing sessions prior to and following exam sessions as required.
- To assist with setting up the circuit(s): putting out clipboards, sharp pencils, and rubbers inside each station.
- Assist with the set-up of equipment (training will be given for the setting up of props or the resetting of station equipment).
- To assist students before the exam begins, ensuring that all students are correctly located and ready for the exam.
- To invigilate the examination circuits and guide students between stations during the exam.
- Direct examiners, patients, simulated patients to the correct stations.
- Be the first response for examiner questions or concerns, raising issues with the lead invigilator or senior examiner quickly and efficiently.
- To vigilantly monitor the room/allocated area throughout the exam in session whilst not disrupting the candidates; and ensuring a calm environment conducive to supporting students to be successful in their exams.
- To ensure that noise levels on the examination circuit are kept to a minimum and that examination conditions are maintained throughout
- To promptly report any incidents that may impact a candidate's performance to the Lead Invigilator, Circuit Lead (Marshall), OSCE Site Lead, or Senior Examiner.
- To ensure that, at the end of the exam, all iPads and materials are collected and returned to the relevant place according to set procedures as advised by the Lead Invigilator.
Qualifications
N/a
Skills
- Must be available for both days (Thursday 1st May 2025 & Friday 2nd May 2025 )
- Available for a prompt start at 09:00 to 17:00
- Professional.
- Observant.
- Shows initiative.
- Handles confidential documents responsibly.
- Available for the full duration of the exam.
- Applicants must NOT be part of the MPharm at King's College London or the Faculty of Life Sciences and Medicine.
OSCE Invigilation
Tuesday 1st April 2025 & Wednesday 2nd April 2025.
Applicants must NOT be part of the MPharm course at King's College London or the Faculty of Life Sciences and Medicine.
Key responsibilities
- To support the Lead Invigilator in carrying out their duties by attending briefing sessions prior to and following exam sessions as required.
- To assist with setting up the circuit(s): putting out clipboards, sharp pencils, and rubbers inside each station.
- Assist with the set-up of equipment (training will be given for the setting up of props or the resetting of station equipment).
- To assist students before the exam begins, ensuring that all students are correctly located and ready for the exam.
- To invigilate the examination circuits and guide students between stations during the exam.
- Direct examiners, patients, simulated patients to the correct stations.
- Be the first response for examiner questions or concerns, raising issues with the lead invigilator or senior examiner quickly and efficiently.
- To vigilantly monitor the room/allocated area throughout the exam in session whilst not disrupting the candidates; and ensuring a calm environment conducive to supporting students to be successful in their exams.
- To ensure that noise levels on the examination circuit are kept to a minimum and that examination conditions are maintained throughout
- To promptly report any incidents that may impact a candidate's performance to the Lead Invigilator, Circuit Lead (Marshall), OSCE Site Lead, or Senior Examiner.
- To ensure that, at the end of the exam, all iPads and materials are collected and returned to the relevant place according to set procedures as advised by the Lead Invigilator.
Qualifications
N/a
Skills
- Must be available for both days (Tuesday 1st April 2025 & Wednesday 2nd April 2025 )
- Available for a prompt start at 09:00 to 17:00
- Professional.
- Observant.
- Shows initiative.
- Handles confidential documents responsibly.
- Available for the full duration of the exam.
- Applicants must NOT be part of the MPharm at King's College London or the Faculty of Life Sciences and Medicine.
About the Role
This post will provide technical support for the Flow Cytometry Service at the Barts Cancer Institute(BCI)/WHRI.
The post-holder will be responsible for day-to-day operation, maintenance and quality control of cell-sorters/analysers and provide users support at all levels. A collaborative approach is essential to cover duties during colleagues' absences or high-demand periods.
Prior knowledge and hands-on experience with BDFACSAria sorters and analysers, along with a strong understanding of Diva software and multicolour Flow Cytometry principles, are essential. Additional training can be provided if needed.
About You
You should have a relevant BSc or equivalent, with a strong background in cancer cell biology or immunology, along with the ability to design, conduct, and analyse complex flow cytometry-based cell assays. Knowledge of PBMC preparation, cell, and tissue culture is desirable. The ideal candidate will be detail oriented, motivated to learn, capable of working both independently and as part of a team, with strong organizational skills, effective communication, and a focus on customer service. Prior experience in a flow cytometry core lab is highly desirable.
About the Institute
BCI is a Cancer Research UK Centre of Excellence whose work aims to transform the lives of those with/at risk of cancer through laboratory-based innovative research, in patients and populations. BCI is internationally renowned in many areas of cancer research. It combines ground-breaking basic research with the expertise of clinicians and scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care. BCI is also a partner in the CRUK City of London Major Centre, which is a Centre of Excellence in Biotherapeutics. It?s one of six institutes within The School of Medicine and Dentistry.
Further information on the responsibilities will be provided upon shortlisting.
Qualifications
BSc or equivalent in relevant subject
Skills
EXPERIENCE
- Experience in the operation of flow cytometers
- Experience in cell sorting
- Experience in other biochemical techniques
- Experience with statistical analysis (Desirable)
- Experience of working in a biomedical research laboratory
- Experience with computer software relevant to laboratory research, data presentation and statistical evaluation of results
- Knowledge of the principles of flow cytometry
- Experience of working in a core service laboratory (Desirable)
- Experience in multiparameter (>10) cell sorting and cytometric analysis, on a variety of cytometers
- Experience with Liquid and Imaging mass cytometry (Desirable)
- Experience with Imaging Flow cytometry (Desirable)
- Experience with Spectral Flow cytometry (Desirable)
- Knowledge of flow cytometry analysis software
SKILLS
- Ability to follow written and oral instructions
- Ability to maintain accurate and up to date records
- Understanding of the research process
- Ability to organise and prioritise own work and organise research within the project timetable
- Computer literacy
- Evidence of good team-working
- Good communication skills
- Analytical skills
- Experience with data analysis and presentation
- Flexible and co-operative
- Self-motivated and hardworking
- Willingness to work flexibly in order to achieve project demands
- Willingness to learn new skills
- *The ability to meet UK ?right to work? requirements.
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