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You can view related vacancies or set-up an email alert notification when similar jobs are added to the website below.
Research Assistant
Job Description
This post will be based in the Immunology Group headed by Mr Wayel Jassam and Dr Yun Ma at the Institute of Liver Studies (ILS) at the King’s College Hospital and King’s College London, Denmark Hill campus. The post holder will be focused on two related projects:
- To perform liver transplantation related research project entitled: Assessing the effect of Andrographolide (Andro) on fatty liver graft in the setting of ex-situ normothermic machine perfusion: Andro is a botanical compound which has a potent anti-inflammatory property by inhibiting NF-κB, Nrf2 activation and in reducing fat content of liver in animal model. The candidate will collect hepatocytes either coming from fatty liver draft or normal liver (leftover from split liver transplant) to set up cell culture after adding different doses of Andro. The effect of Andro on fatty liver hepatocytes or normal will be accessed by several aspects: 1) cell viability; 2) fat content change; 3) mitochondria function; 4) on gene expression by RNA-seq, ChIP-seq analyses etc.
- To construct liver organoid as a 3D model to mimic live liver, the assess will be performed similar to those in vivo. Liver organoid will be constructed using either fatty liver graft or normal liver graft.
The candidate will also be involved in the training of BSc students who are accepted in the current summer vacation for receiving basic training on Immunologic technique
This post is a fixed-term contract with the possibility to further extension, being a part-time post: 20 hours per week for five weeks.
Qualifications
- Medical Qualified or equivalent level in Immunology, including transplantation immunology and tumour immunology
- Expertise in blood processing, liver tissue processing, T cell and B cell immunology in human beings
- Willingness to work as part of a team, to collaborate and help other colleagues when they need
- Excellent verbal and written communication skills
Skills
- Having performed or mastered following techniques: 1) constructing organoid; 2) molecular biology techniques (RNA isolation etc). 3) multiple parameter flow cytometry experimental setup and analysis
- Hepatocyte isolation and culture
- Statistical analysis of data
MORE JOBS LIKE THIS
OSCE Invigilation
Thursday 1st May 2025 & Friday 2nd May 2025.
Applicants must NOT be part of the MPharm course at King's College London or the Faculty of Life Sciences and Medicine.
Key responsibilities
- To support the Lead Invigilator in carrying out their duties by attending briefing sessions prior to and following exam sessions as required.
- To assist with setting up the circuit(s): putting out clipboards, sharp pencils, and rubbers inside each station.
- Assist with the set-up of equipment (training will be given for the setting up of props or the resetting of station equipment).
- To assist students before the exam begins, ensuring that all students are correctly located and ready for the exam.
- To invigilate the examination circuits and guide students between stations during the exam.
- Direct examiners, patients, simulated patients to the correct stations.
- Be the first response for examiner questions or concerns, raising issues with the lead invigilator or senior examiner quickly and efficiently.
- To vigilantly monitor the room/allocated area throughout the exam in session whilst not disrupting the candidates; and ensuring a calm environment conducive to supporting students to be successful in their exams.
- To ensure that noise levels on the examination circuit are kept to a minimum and that examination conditions are maintained throughout
- To promptly report any incidents that may impact a candidate's performance to the Lead Invigilator, Circuit Lead (Marshall), OSCE Site Lead, or Senior Examiner.
- To ensure that, at the end of the exam, all iPads and materials are collected and returned to the relevant place according to set procedures as advised by the Lead Invigilator.
Qualifications
N/a
Skills
- Must be available for both days (Thursday 1st May 2025 & Friday 2nd May 2025 )
- Available for a prompt start at 09:00 to 17:00
- Professional.
- Observant.
- Shows initiative.
- Handles confidential documents responsibly.
- Available for the full duration of the exam.
- Applicants must NOT be part of the MPharm at King's College London or the Faculty of Life Sciences and Medicine.
OSCE Invigilation
Tuesday 1st April 2025 & Wednesday 2nd April 2025.
Applicants must NOT be part of the MPharm course at King's College London or the Faculty of Life Sciences and Medicine.
Key responsibilities
- To support the Lead Invigilator in carrying out their duties by attending briefing sessions prior to and following exam sessions as required.
- To assist with setting up the circuit(s): putting out clipboards, sharp pencils, and rubbers inside each station.
- Assist with the set-up of equipment (training will be given for the setting up of props or the resetting of station equipment).
- To assist students before the exam begins, ensuring that all students are correctly located and ready for the exam.
- To invigilate the examination circuits and guide students between stations during the exam.
- Direct examiners, patients, simulated patients to the correct stations.
- Be the first response for examiner questions or concerns, raising issues with the lead invigilator or senior examiner quickly and efficiently.
- To vigilantly monitor the room/allocated area throughout the exam in session whilst not disrupting the candidates; and ensuring a calm environment conducive to supporting students to be successful in their exams.
- To ensure that noise levels on the examination circuit are kept to a minimum and that examination conditions are maintained throughout
- To promptly report any incidents that may impact a candidate's performance to the Lead Invigilator, Circuit Lead (Marshall), OSCE Site Lead, or Senior Examiner.
- To ensure that, at the end of the exam, all iPads and materials are collected and returned to the relevant place according to set procedures as advised by the Lead Invigilator.
Qualifications
N/a
Skills
- Must be available for both days (Tuesday 1st April 2025 & Wednesday 2nd April 2025 )
- Available for a prompt start at 09:00 to 17:00
- Professional.
- Observant.
- Shows initiative.
- Handles confidential documents responsibly.
- Available for the full duration of the exam.
- Applicants must NOT be part of the MPharm at King's College London or the Faculty of Life Sciences and Medicine.
About the Role
This post will provide technical support for the Flow Cytometry Service at the Barts Cancer Institute(BCI)/WHRI.
The post-holder will be responsible for day-to-day operation, maintenance and quality control of cell-sorters/analysers and provide users support at all levels. A collaborative approach is essential to cover duties during colleagues' absences or high-demand periods.
Prior knowledge and hands-on experience with BDFACSAria sorters and analysers, along with a strong understanding of Diva software and multicolour Flow Cytometry principles, are essential. Additional training can be provided if needed.
About You
You should have a relevant BSc or equivalent, with a strong background in cancer cell biology or immunology, along with the ability to design, conduct, and analyse complex flow cytometry-based cell assays. Knowledge of PBMC preparation, cell, and tissue culture is desirable. The ideal candidate will be detail oriented, motivated to learn, capable of working both independently and as part of a team, with strong organizational skills, effective communication, and a focus on customer service. Prior experience in a flow cytometry core lab is highly desirable.
About the Institute
BCI is a Cancer Research UK Centre of Excellence whose work aims to transform the lives of those with/at risk of cancer through laboratory-based innovative research, in patients and populations. BCI is internationally renowned in many areas of cancer research. It combines ground-breaking basic research with the expertise of clinicians and scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care. BCI is also a partner in the CRUK City of London Major Centre, which is a Centre of Excellence in Biotherapeutics. It?s one of six institutes within The School of Medicine and Dentistry.
Further information on the responsibilities will be provided upon shortlisting.
Qualifications
BSc or equivalent in relevant subject
Skills
EXPERIENCE
- Experience in the operation of flow cytometers
- Experience in cell sorting
- Experience in other biochemical techniques
- Experience with statistical analysis (Desirable)
- Experience of working in a biomedical research laboratory
- Experience with computer software relevant to laboratory research, data presentation and statistical evaluation of results
- Knowledge of the principles of flow cytometry
- Experience of working in a core service laboratory (Desirable)
- Experience in multiparameter (>10) cell sorting and cytometric analysis, on a variety of cytometers
- Experience with Liquid and Imaging mass cytometry (Desirable)
- Experience with Imaging Flow cytometry (Desirable)
- Experience with Spectral Flow cytometry (Desirable)
- Knowledge of flow cytometry analysis software
SKILLS
- Ability to follow written and oral instructions
- Ability to maintain accurate and up to date records
- Understanding of the research process
- Ability to organise and prioritise own work and organise research within the project timetable
- Computer literacy
- Evidence of good team-working
- Good communication skills
- Analytical skills
- Experience with data analysis and presentation
- Flexible and co-operative
- Self-motivated and hardworking
- Willingness to work flexibly in order to achieve project demands
- Willingness to learn new skills
- *The ability to meet UK ?right to work? requirements.
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