The successful candidate will be part of a team testing viral vector gene therapy reagents aimed at treating amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) on a commercially funded project. The aim of the project is to optimise the dose and delivery of gene supplement and knock-down vectors in cellular and animal models of disease as proof of concept and efficacy for potential clinical application. Working with Professor Shaw the candidate will join a team of Technicians and Post-doctoral scientists analysing cells and tissues transduced with plasmid and vector constructs and quantify the effects on target gene expression. For in vivo work the candidate will take care of different mouse colonies from breeding to sacrifice stage (including behavioural phenotyping studies), harvest and prepare tissues for histological sectioning, staining, imaging and quantitative analyses. In vivo work will be conducted over two different sites (Denmark Hill and Waterloo Campus). All experiments will be undertaken at a very high standard and all data treated with complete confidentiality.
Longer-term employment opportunities for will arise for the right candidates
Qualifications
- BSc in Neuroscience or equivalent biological field
- Personal License Rodent Handling
SkillsExperience
Essential Experience in Animal handling
In vivo experimental methods
Rodent colony maintenance and genotyping
Experience in rodent colony maintenance and genotyping
Expertise in animal tissue processing and immunohistochemistry
Experience in microscopy
Ability to work independently and within a team
Administrative skills for careful record keeping
Conscientious and organised
Ability to time manage appropriately
Willing to work during some weekends and bank holidays
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