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Gene Therapy Junior Animal Laboratory Technician

£39,039 - £39,039
 

Job Description

The successful candidate will be part of a team testing viral vector gene therapy reagents aimed at treating amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) on a commercially funded project. The aim of the project is to optimise the dose and delivery of gene supplement and knock-down vectors in cellular and animal models of disease as proof of concept and efficacy for potential clinical application. Working with Professor Shaw the candidate will join a team of Technicians and Post-doctoral scientists analysing cells and tissues transduced with plasmid and vector constructs and quantify the effects on target gene expression. For in vivo work the candidate will take care of different mouse colonies from breeding to sacrifice stage (including behavioural phenotyping studies), harvest and prepare tissues for histological sectioning, staining, imaging and quantitative analyses. In vivo work will be conducted over two different sites (Denmark Hill and Waterloo Campus). All experiments will be undertaken at a very high standard and all data treated with complete confidentiality.



Longer-term employment opportunities for will arise for the right candidates



Qualifications

 




  • BSc in Neuroscience or equivalent biological field

  • Personal License Rodent Handling 



Skills

Experience



Essential Experience in Animal handling 



In vivo experimental methods 



Rodent colony maintenance and genotyping 



Experience in rodent colony maintenance and genotyping



Expertise in animal tissue processing and immunohistochemistry



Experience in microscopy



Ability to work independently and within a team



Administrative skills for careful record keeping



Conscientious and organised



Ability to time manage appropriately



Willing to work during some weekends and bank holidays

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The Laboratory of RNA networks is seeking a Research Assistant  to join a team of researchers under the supervision of Professor Jernej Ule working on the dynamics of ribonucleoprotein complexes (RNP) that assemble on the 3’ UTRs of neuronal mRNAs (http://ulelab.info/). The group focuses on mechanisms of RNP assembly, as part of a project funded by the Wellcome Trust. 



The post holder will contribute to the project to develop computational approaches to study how RNA-binding proteins  regulate alternative splicing. Primary focus will be computational studies of data produced by iCLIP, RNA-seq and related methods) and developing the work towards relevant publications. 



The post is based at the UK DRI, https://ukdri.ac.uk/ 



Maurice Wohl Clinical Neuroscience Institute, King's College, Denmark Hill Campus  





  • To conduct high quality research under the supervision of Professor Ule, and in collaboration with other members of the Ule group. 




  • Develop and test new software, analyse data, build new hypotheses and independently design further experiments. 







  • Prepare figures summarising the results and play a leading role in writing the manuscripts. 




  • Continue professional development, including participation in staff development and review procedures in accordance with UCL guidelines, including annual formal appraisal 




  • Contribute to the department’s multidisciplinary research projects within the strategy. 




  • Present at international conferences as well as internal meetings at UCL, and meetings with external collaborators. 




  • Regularly interact with collaborators and coordinate joint work. 







  • Ensuring the highest standard of record keeping, maintaining accurate, complete, and up to date records. 




  • Ensuring confidentiality is maintained as applicable. 




  • Attending and contributing to Departmental, Institutional and other meetings as appropriate. 




  • Acting at all times in accordance with the highest professional standards, and ensuring that these are maintained in the delivery of all aspects of researc





Qualifications

PhD in Computational Biology or a related discipline 



Skills


  • Experience in developing new computational tool 




  • Experience with mechanisms of RNA regulation 




  • Computational proficiency at advanced level 




  • Excellent oral and written communication skills 







  • Strong problem solving abilities 




  • Excellent organisational skills, with the ability to work efficiently on multiple sites 




  • Excellent inter-personal skills with an ability to work co-operatively in a multidisciplinary setting 




  • Resourceful and able to act on own initiative 




  • Interested in research and a commitment to supporting high quality research 







  • Meticulous and accurate in all aspects of work 

     



Teaching fellow with neuroscience knowledge for urgent level 6 marking



Qualifications

Ideally HEA fellowship



Skills

Marking

Graduate Teaching Assistant roles for the MSc Developmental Psychology & Psychopathology programme 2024-25



We are inviting applications for teaching opportunities on the DEV-PP MSc programme this coming year.



We are looking to employ PhD students as graduate teaching assistants on many of the DEV-PP modules, as described below.



If you have any questions about the role or the modules, please contact Kitty Jones (catherine.2.jones@kcl.ac.uk)




  • Developmental Psychopathology 1: Perinatal period and Infancy

  • Teaching October-November 2024

  • Introduction to Statistics

  • Teaching October-November 2024

  • Nature & Nurture 1: Approaches to Addressing Key Questions in Psychopathology

  • Teaching November-December 2024

  • Nature & Nurture 2:  Genomic Approaches in Psychopathology

  • Teaching February-March 2025

  • Psychological Approaches to Treatment

  • Teaching February-March 2025

  • Placement

  • Main placement period February-April 2025

  • Dissertation

  • Main dissertation period April-August 2025



Key Responsibilities




  • Delivery of agreed package of teaching activities to a high standard, under the direct supervision of a member of academic staff. These activities may include seminars, classes, tutorials, lab sessions, other small group work to develop student skills, demonstration for experiments/techniques in lab-based science and computing, and/or mentoring support for UG or PGT project work. Students will not normally be involved in lecturing, but in some cases may be asked to lead lectures if the topic falls within their specialist field.

  • Participation in appropriate training – including mandatory courses/sessions (e.g. courses, induction sessions).

  • Careful and proportionate preparation for teaching activities. In some instances, materials will be provided by departments/faculties.

  • Maintenance of information and resources on KEATS and interaction with students via the VLE.

  • Attendance at lectures where needed/requested to ensure consistency of module delivery.

  • Routine administration and correspondence associated with teaching delivery.

  • Liaison with senior colleagues regarding contributions to the module.



GTAs are not expected to:




  • lead lectures, unless they have accepted to do so on a very occasional basis, in their specialist field

  • provide pastoral support to students or act as a personal tutor

  • be involved in Open Days or admissions activities

  • provide students with references

  • set assessments

  • be available to students at all times

  • carry out unremunerated additional work on an ad hoc basis.



{The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.}



Qualifications

Education / qualification and training



Excellent subject knowledge of Developmental Psychology and Psychopathology as appropriate to the specific teaching role – For example, as evidenced by excellent performance in a BPS-accredited undergraduate degree in a psychological science



Undertaking psychological research at King’s College London, either as a PhD student or as a postdoctoral researcher.



Skills

Skills required



Knowledge / skills



Effective interpersonal skills, both written and verbal, to support and liaise with staff and students



Ability to provide advice to students on study skills and assist with any learning problems



Experience



Experience of facilitating or leading group work, activities or discussion.



Experience of adapting own skills to new circumstances.



Personal characteristics/other requirements



Ability to self-reflect on teaching design and delivery and act on feedback for future improvements.



A commitment to delivering high quality education as part of a team.



Diligent in preparing for teaching sessions and assessment activities; including undertaking preparatory reading, planning, and familiarization with assessment briefs and marking criteria.



Role specific requirements



Ability and willingness to engage in relevant departmental training and introductory pastoral support training.



Keep abreast of current literature in subject areas being taught.

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